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There is an observable decrease, of around 10%, in the duration of exercise until exhaustion in smokers, which is attributable to a reduction in O2 production in the metabolically active tissues, as a result of arterial O2 desaturation, and to the insufficiency of the O2 transportation, supply and uptake system ( Figure 2 )

This is the single most important context for the comparison because it is where the most dramatic and well-documented environmental harm from cigarette smoking occurs

"Electronic cigarettes and vaping: a new challenge in clinical medicine and public health

Late 20th Century By the late 20th century, the awareness of smoking's health risks increased, and governments had begun heavily restricting cigarette marketing

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