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2025;3:1008132 DOI: Received: September 03, 2025 Accepted: September 23, 2025 Published: October 30, 2025 Academic Editor: Alessandra Tolomelli, University of Bologna, Italy The article belongs to the special issue Innovative Therapeutics in Hepato-Gastroenterology Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading cause of cirrhosis, hepatocellular carcinoma, and liver-related mortality worldwide

The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation

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