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The increase in cAMP activates downstream signaling cascades, primarily through protein kinase A (PKA), and upregulates the expression of melanogenic enzymes, resulting in increased eumelanin synthesis and visible skin darkening (Figure 4)

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#SleepMedicine #Endocrinology #Cardiology #GLP1 #CPAP #Obesity #MetabolicHealth #NetworkMetaAnalysis #EvidenceBasedMedicine To view or add a comment, sign in More Relevant Posts SLEEP AND CARDIOVASCULAR HEALTH Continuing Medical Education (CME) Program Sleep disorders, particularly Obstructive Sleep Apnea (OSA), have been increasingly recognized as closely associated with many cardiovascular diseases such as hypertension, arrhythmias, heart failure, and stroke