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Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

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By contrast, NAC treatment did not reduce elevated levels of unique PPP sugars, S7P and R5P, suggesting that altered PPP activity lies upstream of GSH depletion in the order of metabolic signaling defects in SLE

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