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Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome

Primary Research Areas NNMT enzymology and pharmacology the lead first-in-class selective small-molecule NNMT inhibitor used to validate the entire target class [1,2]

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Isoleucine: Deters muscle degradation and accentuates recovery

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity