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The Reason: Semaglutide provides biological appetite suppression, whereas intermittent fasting relies on behavioral discipline to manage hunger, which often leads to "overcompensation" (eating too much) during the feeding window

Discussion The efficacy of conventional chemotherapeutic agents is often limited by the robust antioxidant defense mechanisms inherent in cancer cells, which help neutralize the reactive oxygen species (ROS) generated during chemotherapy

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In contrast, a global pharmacovigilance study did report a significant and disproportionate association between semaglutide and reports of ischemic optic neuropathy (including NAION) [117]