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Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G

Research Summary Dihexa is a small peptide angiotensin IV derivative shown in preclinical studies primarily using rodent models to significantly enhance synaptogenesis, cognitive function, and neuroprotection by activating the HGF/c-Met pathway

Moreover, the MCD diet model, while useful in inducing liver injury and inflammation, leads to metabolic alterations such as weight loss and decreased insulin levels that contrast starkly with human MASH, which is typically associated with obesity and insulin resistance