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GLP-1/GIP Receptor Dual Agonists Gastric inhibitory polypeptide (GIP) is a peptide hormone released by K-cells of the small intestine in response to food, which increases pancreatic insulin release

Skin-related sensory changes, including dysesthesia and altered skin sensation, also fall here based on clinical trial data showing 1-3% incidence

Despite growing excitement around GLP-1 therapies, endocrinologists are careful not to present them as risk-free

In 2023, semaglutide (the active ingredient in Wegovy & Ozempic) was added to updated PCOS treatment guidance due to its ability to address insulin resistance

However, with the shortage resolved, the FDA expects these compounded versions to be phased out, as they are not FDA-approved and may pose safety risks