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When activated, they aggregate and tend to plug the wound with red blood cells and various fragmented proteins, such as von Willebrand factor (a clot-forming protein produced by injured vascular cells)

Instead, its flagged as waste by your kidneys and flushed out before it ever gets a chance to cross the blood-brain barrier

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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]

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