Liver scarring is very serious, with the potential to disrupt the organs functionality and potentially lead to liver failure
Notably, a Business Group on Health survey fielded earlier this year found that 87% of employers expect the availability of oral medications to increase demand for GLP-1s, while only 9% predict a price drop
Significant reductions in albuminuria are confirmed to correlate strongly with improved renal outcomes in diabetic patients, reinforcing its utility as a prognostic marker [39]
This drug class includes short-acting GLP1-RA exenatide, lixisenatide and beinaglutide, as well as long-acting GLP1-RA dulaglutide, semaglutide, liraglutide and albiglutide (discontinued in 2017 at the request of the marketing authorisation holder due to steady decline in sales)
In some cases, switching to a different medication with a different pharmacokinetic profile may be appropriate, as individual responses vary