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MSM: Although in many products, the evidence is very limited for MSM

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Treatment: Moisturizers, oral/topical medications, lifestyle changes

However, he adds, S-curves are hard to come across empirically because they require substantially more variance in the data than what the usual datasets include

Klein A, Schiffner R, Schiffner-Rohe J, Einsele-Kramer B, Heinlin J, Stolz W, Landthaler M