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26 For genetic sensitivity analyses, we used other models with different adjustment/exclusion criteria: (1) adjusted for BMI and COPD due to their association with the CHRNA3 rs1051730 genotype and smoking, 29,39,4547 (2) adjusted for prevalent tobacco-related cancer, (3) exclusion of individuals with prevalent tobacco-related diseases (including tobacco-related cancer, COPD, and ischemic heart disease), and (4) exclusion of individuals with infections within the past 4 weeks, as this may affect the white blood cell counts

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