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Novo said its own testing found ingredients used to make compounded versions of injectable Wegovy contained impurities of up to 86%

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Some observational studies have noted changes in bone turnover markers with GLP-1 use, though these biochemical changes do not necessarily translate to clinically significant bone loss or increased fracture risk

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GLP-1 receptor agonists are peptide-based biologics that are absorbed directly into the systemic circulation from subcutaneous tissue, making them independent of intestinal absorption processes that might be affected by altered bile flow