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The positive effects of the diet are attributed to maintaining a state of nutritional ketosis, which is also a marker for compliance to the diet and assessed by elevated levels of ketone bodies such as acetoacetate in the urine, beta-hydroxybutyrate (BHB) in the blood, and acetone in the breath (7, 8)

2023 American Society of Anesthesiologists Practice Guidelines for Preoperative Fasting: Carbohydrate-containing Clear Liquids with or without Protein, Chewing Gum, and Pediatric Fasting Duration-A Modular Update of the 2017 American Society of Anesthesiologists Practice Guidelines for Preoperative Fasting

Moreover, studies conducted on ruminants showed that a high intake of protein affects ovarian activity through non-Luteinizing hormone (LH) mediated pathways (91), including the ovarian IGF system, which enhances intrafollicular IGF leading to increased follicle-stimulating hormone (FSH) sensitivity (92)

Four-week cycles align conveniently with single-vial protocols

Novel agents effective against solid tumors: the diarylsulfonylureas