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Under the influence of thiolase (acetyl-CoA acetyltransferase 1, ACAT1), CoA-SH is detached from one molecule of acetyl-CoA, and acetoacetyl-CoA (AcAc-CoA) is formed

Cancer cell-specific metabolic pathways or nutrient addiction, such as glycolysis, glutaminolysis, or other energy stress dependence, can also be utilized as therapeutic targets

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One of the clinical issues associated with renal Fabry disease is the low therapeutic efficacy of ERT when treatment is started in the advanced stages 11,12

doi: 10.1046/j.1365-2958.2003.03496.x 9 AntunesA.GolfieriG.FerliccaF.GiulianiM