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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

They stimulate insulin release when blood sugar rises

When resistance trained athletes were provided an acute supplement of it before performing Wingate cycle sprints there was an observable support of anaerobic work capacity, peak power production, and lactate accumulation and clearance compared to the baseline [14, 15]

The decision depends on weight loss progress, side effects, health markers, maintenance planning and provider guidance

It serves several functions, including fermentation of food, protection against pathogens, immune response stimulation and vitamin production