GLP-1 (Glucagon-like peptide-1) injections are a class of medications that mimic the action of the natural GLP-1 hormone in the body, stimulating insulin secretion, suppressing appetite, and delaying gastric emptying, thereby promoting weight loss
Far along in research and development is Eli Lillys retatrutide, a triple agonist that adds glucagon to GLP-1 and GIP, and the requisite studies are underway.1,14 In addition, theres cagrisema from NovoNordisk, a blend of semaglutide (GLP-1 agonist) and a long-acting amylin (another pancreatic hormone) analog cargrilintide
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However, the modest effect does not negate the potential value of these drugs, especially for conditions where few effective treatment options exist, for example, dementia, Al-Aly said
This project will use an emulated trial design to see if starting GLP-1/GIP drugs actually leads to fewer heart problems, especially in communities with more health disparities