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It is thought that portal hypertension (high blood pressure in the livers venous system) due to NAFLD may impair the kidneys ability to regulate sodium levels and blood pressure, triggering dysfunctional compensatory mechanisms and setting the stage for CKD

Mitochondria, as a primary source of ROS, contribute to mitochondrial swelling and apoptosis when ROS levels become excessive

L., Kricker, A., Gayathri, St

Wu G, Ruben MD, Schmidt RE, Francey LJ, Smith DF, Anafi RC, Hughey JJ, Tasseff R, Sherrill JD, Oblong JE, Mills KJ, Hogenesch JB (2018) Population-level rhythms in human skin with implications for circadian medicine

10.1186/s12974-020-1710-2 318 ZaissA