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GLP-1 medications vary, but most start working within hours, with peak effects depending on the specific drug

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Cycling gives you control over intensity

Notably, More recent studies suggest that PYY signaling interacts synergistically with GLP-1 and other satiety peptides, raising the possibility that lower-dose combination strategies could harness its anorectic effects while minimizing intolerance ( 5.2 Oxyntomodulin as an endogenous polypharmacologic signal As discussed in Section 4.4, it also plays a central role in appetite regulation in the context of metabolic peptides