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As there is some reserve there, some loss of lean mass is expected

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Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, et al

The study cohort was derived from the Semaglutide Treatment Effect in People with Obesity (STEP) 9 trial, a multicentre (61 sites across 11 countries) long-term Semaglutide assessment adopting double-anonymized, randomized, placebo-controlled study methodologies