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This gene, this MC1R gene is associated with a pathway that relates to something that I've talked about on this podcast before during the episode on hunger and feeding, and this is POMC

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Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity

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