ATP is broken down by ATPases and 5-nucleotidase to adenosine, which is taken up by varicosities to be resynthesized and reincorporated into vesicles
Introduction Inflammatory bowel diseases (IBDs), including Crohns disease (CD) and ulcerative colitis (UC), are chronic intestinal inflammatory conditions that might be caused by environmental, genetic, and immunological imbalances ( / ), have been established to study the underlying mechanisms ( It is well accepted that dysregulated immune response plays a critical role in colitis ( Glucagon-like peptides (GLPs), including GLP-1 and GLP-2, are secreted by the endocrine cells in the gut up on nutrient uptake ( in vivo ( The role of incretin hormones in bowel disease has not been demonstrated until recently (32, 33)
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Hawkes, Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Children and Adolescents with Obesity: A Meta-Analysis
Dis Model Mech 3:652662 ahin A, Held A, Bredvik K et al (2017) Human SOD1 ALS mutations in a drosophila knock-in model cause severe phenotypes and reveal dosage-sensitive gain and loss of function components