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B12 is a water-soluble vitamin, so the body excretes what it doesnt need
Consequently, the plasma half-life of the GLP-1 albumin fusion was reduced from 1.3 days to 0.9 days in the human FcRn Tg32 mice
This reduces large fluctuations in appetite and energy that often drive overeating
Moreover, overexpression of mucin MUC13 exacerbates TJ dysfunction through the janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) and rho-associated coiled-coil containing protein kinase 2 (ROCK2)/mitogen-activated protein kinase (MAPK) signaling pathways, and IL-22 can activate these pathways [73]
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