In vitro functional analyses confirmed their mature hepatocyte characteristics: they showed high transcription and protein expression of ALB, A1AT, CYP3A4, and CYP2C9, comparable to primary human hepatocytes (PHs)
The long-term safety of ferroptosis inducers (e.g., potential off-target effects on normal renal tissue or promotion of secondary tumors) also remains unevaluated in prolonged preclinical studies
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