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McDuffie JR et al

While weight reduction appears to be the dominant mechanism, these agents may also exert direct renal, vascular, and neurohormonal effects that contribute independently to blood pressure lowering, Muskiet told Healthline

Binding of GLP-1 or a synthetic hormone receptor agonist to the GLP-1R on the surface of HEK-Blue GLP-1 cells triggers a signaling cascade leading to the activation of the CRE-binding Protein (CREB) pathway and the subsequent production of SEAP

Importantly, these arent just appetite effects the animals specifically reduce alcohol-seeking behavior even when food is held constant, suggesting an independent mechanism acting on reward circuitry

Data Availability No data was collected in the development of this manuscript