Yes, low-quality or "raw" shilajit often contains heavy metals like lead, arsenic, and mercury, which are known to be toxic to the cardiovascular system
What Happens When Recycling Slows Down In patients, the enzyme GR, which is responsible for recycling spent/oxidised glutathione back to fully loaded, slows down, which leads to the accumulation of oxidised glutathione (GSSG) and the depletion and inability to produce GSH
10.1007/BF00686159 Cancer Chemother
The pathogenesis of polycystic ovary syndrome (pcos): the hypothesis of pcos as functional ovarian hyperandrogenism revisited
doi: 10.1016/j.trsl.2020.03.012, Summary Keywords aging, exercise, L-citrulline, leucine, musclevasculature, cognitive frailty, successful aging, neurovascular coupling Citation Lin X, Zhang Y, Pu J and Peng Y (2026) Targeting musclevasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention
