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Understanding the mechanism helps explain why its effects are so broad

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331,332 Multiple PD-associated genes, such as LRRK2, SYNJ1, DNAJC6, and DNAJC13, regulate synaptic endocytosis, autophagy, lysosomal function, and endolysosomal trafficking, underscoring the intertwined regulation of vesicular dynamics and proteostasis in dopaminergic neurons

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