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When Standard Escalation Falls Short Some individuals respond better to modified escalation approaches

Men with Class I obesity lost an average of 17.4 kg (38 pounds), while those with Class III obesity lost 25.3 kg (56 pounds)

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Questions regarding the cardiovascular safety of drugs prescribed for T2DM arose as individuals treated with sulfonylureas and insulin showed an increased incidence of major adverse cardiovascular events (MACEs: death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) [18, 19]

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