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In three of these studies there was a significantly greater improvement with cyclobenzaprine HCl than with diazepam, while in the other studies the improvement following both treatments was comparable

Ensure adequate hydration while taking NSAIDs to protect kidney function, especially during illness

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Power calculations suggest that previous studies would have had limited power to detect an effect size similar to that identified in our study (Supplementary Table 23), and also differed in terms of drug type, disease cohort and analytical choices

An inquest, which ended on 20 November 2023, concluded that Gladstone died as a result of a generally unknown interaction between warfarin and tramadol, which caused exceptional thinning of her blood