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Bioinformatics 41 , btaf269 (2025)

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[63] In randomized controlled clinical trials, there is a notable 3 to 4-fold increase in GMIs, especially in females, with 13.6%, 10.6%, 8.4%, and 5.4% incidences in low-dose Ertugliflozin, Canagliflozin, Dapagliflozin, and Empagliflozin groups, respectively

Discussion As an essential factor in mitochondrial FA -oxidation, L-carnitine has been used to alleviate fat accumulation-related metabolic syndromes in humans and other mammals for decades 8,9,30