In order to limit ROS production and mitigate potential damage, cells have developed a wide range of antioxidant systems, including superoxide dismutase, catalase, glutathione peroxidase, vitamin E, and vitamin C
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Therefore, the relationship between MASLD development/progression and the changes in antioxidant systems has been the subject of numerous various studies, although the results obtained have been quite inconsistent
However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines
