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177,179181 Like vitamin C, hesperidin exerts its anti-inflammatory effect by inhibiting the NF-B signaling pathway and reducing inflammatory cytokines, such as TNF-, IL-6, and IL-1

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Nonetheless, two IV studies have been published related to Parkinsons disease, one open-label which found significant improvement and a slowing of the disease, and one randomized and double-blinded which found only mild symptomatic improvement