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Abstract Background Glucagon-like peptide-1 (GLP-1) receptor agonists were recently approved for obesity treatment in children 1217 years by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA)
Semaglutide Therapy and Its Metabolic Mechanisms Semaglutide is a GLP-1 receptor agonist that mimics glucagon-like peptide-1, a hormone regulating blood sugar, appetite, and satiety
Muscle is metabolically active tissue - it burns calories just by existing
Its interactions trigger downstream signaling that affects cellular responses
Variants in l-carnitine related genes, SLC22A4 and SLC22A5 , are associated with ischemic heart disease [6]
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