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Eryptotic erythrocytes are identified by the externalization of the membrane PS, which attracts the phagocytic cell-like macrophages [230, 404], followed by engulfment and destruction of both the host cell and intraerythrocytic pathogen [404]

[15]Rashid A, Schutte BJ, et al

Noradrenaline and/or cortisol, whose levels both increase with advancing age, can impede receptor activity at several locations, leading to desensitization of the neuronal insulin receptor in late-onset sporadic AD disease

Moreover, PS externalization, which is one culmination point of eryptosis signaling, is known to be immunosuppressive and antiinflammatory [233]