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The intervention involved a once-daily administration of oral semaglutide at dose of 14 mg, while the comparators consisted of once-weekly injectable semaglutide at 1.0 mg, once-weekly dulaglutide at 1.5 mg, once-daily liraglutide at 1.8 mg, twice-daily exenatide at 10 ug, and once-daily lixisenatide at 20 ug (Supplementary Table S2)