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This is because: GLP-1 agonists: Slow gastric emptying, enhance insulin secretion, regulate hepatic glucose Amylin agonists: Suppress appetite centrally, slow gastric emptying via distinct pathways Together: Complementary mechanisms produce additive/synergistic effects on weight loss Cagrilintide Monotherapy Trials Initial clinical development focused on establishing the safety, tolerability, and efficacy of cagrilintide as a standalone therapy for weight management

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Eguchi N., Vaziri N.D., Dafoe D.C., Ichii H

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