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These diseases are typically characterized by persistent inflammatory responses and tissue damage, and their onset and progression involve the combined effects of genetic susceptibility, environmental factors, and dysregulated immune regulation ( Macrophages exhibit marked functional plasticity, and their phenotypes can dynamically change in response to microenvironmental signals

Finally, and critically, the field must adopt higher standards of reporting, including full chemical and taxonomic characterization of natural products, detailed pharmacological data, and stringent assessment of data validity to minimize false positives and enhance reproducibility

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