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Causes and Risk Factors of Ovarian Cysts Your risk of developing an ovarian cyst is increased by: Drugs that stimulate ovulation, including the fertility drug clomiphene (Clomid) Pregnancy Underlying conditions such as hormone disorders, endometriosis, and polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS) A severe pelvic infection A previous ovarian cyst Editors Note: Following a May 2026 global consensus, polycystic ovary syndrome (PCOS) is now officially called polyendocrine metabolic ovarian syndrome (PMOS), highlighting the metabolic roots of the condition

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