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Introduction Picture this: you wake up one morning and catch a glimpse of your reflection, noticing fine lines and dullness that werent there before

Proteomic analysis Cells were seeded in 10-cm dishes and cultured for 7 days in cystine-free medium supplemented with heavy isotope-labelled 13 C 6 , 15 N 2 -cystine (Cambridge Isotope Laboratories, CNLM-4244-H)

Among genetic predispositions, specific human leukocyte antigen (HLA) genes are strongly implicated, such as HLA-B51 in BD ( Figure 1 ) ( Figure 1 Based on current evidence, we hypothesize that dysbiosis of the gut microbiome and its metabolites trigger gut inflammation and increase intestinal permeability (leaky gut)

doi: 10.1530/jrf.0.0560439

For most disease-modifying drugs, however, the adage no inflammation, little benefit remains largely true (Lublin et al., 2022)