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Mitochondria-related pathways Reactive oxygen species (ROS) are a byproduct of aerobic metabolism that are mainly derived from mitochondrial metabolism and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) on the cell membrane, and excessive ROS or the inappropriate location of ROS can damage cells [40]

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Cone photoreceptors were labeled with anti-Opsin Blue (Merck, cat