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Navale, A

Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH (fragment- 1) Fmoc-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-Val-Ser(Oxa)-OH (fragment-2) Fmoc-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Gly-OH (fragment-3) Fmoc-Gln(Trt)-Ala-Ala-Lys(C18 diacid mono-t -butyl -y-Glu(AEEA-AEEA)-OtBu)-Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-OH (fragment-4) Fmoc-Leu-V al-Arg(pbf)-Gly-Arg(pbf)-Gly-OtBu (fragment- 5) b) condensing Fmoc-Leu-V al-Arg(pbf)-Gly-Arg(pbf)-Gly-OtBu (fragment-5) with Fmoc- Gln(Trt)-Ala-Ala-Lys(C18 diacid mono-t-butyl-Y-Glu(AEEA-AEEA)-OtBu)-Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-OH (fragment-4) in presence of coupling agent and solvent in in-situ manner followed by deprotection in presence of base to obtain 15 amino acid peptide chain

Cognisant of the positive effects of triheptanoin in other brain and neuromuscular disorders and its mechanism of action, we hypothesized that treatment with triheptanoin, being an alternative substrate to glucose provides degenerating cells with much needed energy, which can delay cell death and thereby the onset of motor symptoms in the ALS mouse model

Liz takes glutathione most evenings and has seen a huge difference in her energy levels

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