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Dicke, a Dutch paediatrician, observed that the condition of children with coeliac disease improved during the food shortages of World War II, only to relapse after cereal supplies were restored.[3] Most commonly diagnosed present in Western Europe, North America and Australia, it is also found in many other countries and slightly more frequently in the female population

Half the participants received a supplement containing 560 milligrams of nitrate while the others received a placebo with very little nitrate

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167,168 In hepatocytes, elevated lipid load and insulin resistance increase mitochondrial -oxidation activity, accompanied by electron leakage and respiratory chain disruption, resulting in substantial ROS production, which exacerbates lipid peroxidation, autophagic dysfunction, and pyroptosis

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