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Extracellular superoxide dismutase (SOD), cytosolic copper, zinc SOD, and mitochondrially located manganese SOD (MnSOD) play a major role in the formation of hydrogen peroxide, whereas glutathione peroxidases (GPxs), catalase, and peroxiredoxins all play a role in the enzymatic catabolism of this ROS

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A 2016 review in Growth Hormone and IGF Research noted that pulsatile GH secretion produces more physiologic IGF-1 profiles than continuous GH infusion, a property relevant to secretagogue-based protocols