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Phase II Conjugation Glutathione binds to these intermediates through conjugation the crucial step that makes toxins water-soluble

[4] Jastreboff AM, et al

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Celastrol and Fer-1 reduce HG-induced oxidative stress and reverse ferroptosis signalling in HK-2 cells HK-2 cells were treated with various concentrations of celastrol (50, 100, 200, 400 and 800 nM) for 24 h