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Irritation within the gut impairs normal digestive functions and causes permeability, allowing particles to pass into the bloodstream, known as leaky gut

Autoimmune diseases: molecular pathogenesis and therapeutic targets

The peptide also restores melatonin secretion rhythms in aged animals and stabilizes genomic integrity by reducing age-associated chromosomal aberrations

Clinical Biochemistry 29 , 225229 (1996)

Findings from animal and in vitro research suggest hesperidins positive effects on blood glucose and lipid levels may be related in part to activation of the AMP-activated protein kinase (AMPK) pathway (Jia 2015