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Constipation develops because tirzepatide slows gastric motility throughout the entire digestive tract, not just the stomach

Beyond that, the supplements guide for GLP-1 users recommends considering: Electrolytes: Especially during the first few weeks when GI side effects are most prevalent B12: Often combined with GLP-1 agonists in compounded formulations, as semaglutide with B12 and tirzepatide with B12 combinations demonstrate Fiber: To support digestive regularity, which can be disrupted by altered gastric motility Biotin: Particularly if hair thinning occurs, as a preventive measure alongside adequate protein Exercise during retatrutide use Resistance training is more important than cardio during a GLP-1 protocol

Notably, both drugs, particularly the higher doses of tirzepatide, were associated with an increased incidence of gastrointestinal adverse events

Patients with autoimmune conditions affecting the pancreas, such as type 1 diabetes or autoimmune pancreatitis, require specialized consideration