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In addition to the neuropharmacological effects of GIPR antagonism, we also demonstrate that CNS GIPR KO prevents body weight gain under HFD challenge, supporting the role of CNS GIPR as a primary driver of body weight differences seen in the whole-body GIPR KO mouse 41
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Specifically, semaglutides directly activate GLP-1 receptors in neurons involved in appetite in the hypothalamus and the hindbrain
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