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Throughout the proliferative phase, there is widespread cellular proliferation in all of the principal cellular compartments of the endometrium including epithelial, stromal and vascular cells

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It is mainly found in the brush borders of epithelial cells of the proximal convoluted tubules in the kidney, in the small and large intestine, prostate tissue, hepatocytes, fibroblasts and in activated leukocytes [3033], preferentially cleaving peptide hormones containing a position two alanine or proline [27]