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2), indicating the formation of larger aggregates, which were also observed by DLS (Supplementary Fig

This comparison examines whether retatrutide's triple agonist mechanism offers clinically meaningful advantages over semaglutide's proven single-agonist approach, while acknowledging the fundamental asymmetry in evidence quality between a fully approved drug and an investigational compound

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GLP-1RAs, in addition, stimulate the activity of the carbonic acid decarboxylase enzyme, increasing the decarboxylation of glutamate into GABA, and hence elevating brain GABA levels [140]