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Upregulation of miR-21 or interference with BDH2 expression enhanced TET protein activity, resulting in decreased DNA methylation of the BCL6 gene promoter, ultimately promoting BCL6 gene expression [26]

These molecular findings were well-aligned with the behavioral and clinical scores (CGI-S, CGI-I) as secondary endpoints

The elements to consider in such a composite profiling, for a principal component analysis, could be for instance the following

Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations

A study in monocytes from people with ASD found a positive result by regulating the Nrf2 system in an in vitro LPS-induced inflammatory model (271) and many other studies have reported the abnormalities of the Nrf2 system in ASD individuals (272, 273)